AMACR Polyclonal Antibody

Verified Samples in WB: Rat kidney, Rat liver, Rat intestine, Mouse kidney, Mouse liver
Verified Samples in IHC: Mouse kidney, Mouse kidney, Human kidney

WB 1:1000-1:3000, IHC 1:150-1:300

Polyclonal

IgG

Recombinant Mouse Amacr protein expressed by E.coli

AMACR

2-methylacyl-CoA racemase,  AMACR,  AMACRD,  Alpha methylacyl CoA racemase,  Alpha-methylacyl-CoA racemase,  Amacr,  Macr1,  RACE,  RM, 2 methylacyl CoA racemase

42 kDa

40 kDa

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Cell Biology, Metabolism, Signal Transduction

Unconjugated

AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer (PCa). However,AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa,suggesting a hormone-dependent expression of AMACR. It has 3 isoforms produced by alternative splicing. Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) and congenital bile acid synthesis defect type 4 (CBAS4).