AMPK alpha2 Polyclonal Antibody

Verified Samples in WB: Human Hep G2, Human Hela, Mouse NIH/3T3
Verified Samples in IHC: Human breast
Verified Samples in IF: Human MCF7

WB 1:500-1:1000, IHC 1:100-1:200, IF 1:100-1:400

Polyclonal

IgG

Recombinant Rat Ampk2 protein expressed by E.coli

AMPK

5'-AMP-activated protein kinase catalytic subunit alpha-2, AAPK2, ACACA kinase, AMPK alpha 2 chain, AMPK subunit alpha-2, AMPK2, AMPKa2, AMPKalpha2, Acetyl-CoA carboxylase kinase, HMGCR kinase, Hydroxymethylglutaryl-CoA reductase kinase, PRKAA, PRKAA2, Protein kinase

62 kDa

62 kDa

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Cancer, Cardiovascular, Metabolism, Signal Transduction

Unconjugated

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.