Angiotensinogen Polyclonal Antibody

Verified Samples in WB: Mouse lung, Mouse kidney, Mouse heart, Mouse spleen
Verified Samples in IHC: Mouse kidney, Rat kidney

WB 1:2000-1:5000, IHC 1:100-1:300

Polyclonal

IgG

Recombinant Mouse Angiotensinogen protein

Angiotensinogen

A,  AGT,  AI265500,  Alpha 1 antiproteinase antitrypsin,  Ang,  Ang I,  Ang II,  Ang III,  AngII,  Angiotensin I,  Angiotensin II,  Angiotensin III,  Angiotensin-3,  Angiotensinogen,  Angiotensinogen (PAT), Aangiotensinogen (serpin peptidase inhibitor clade A member 8)

52 kDa

52 kDa

Secreted

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Cancer, Cardiovascular, Metabolism, Signal Transduction

Unconjugated

Angiotensinogen is a precursor of angiotensin II (Ang II),is expressed and synthesized largely in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. It has a key role in mediating vascular constriction and regulating salt and fluid homeostasis. The resulting product,angiotensin I,is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Mutations in this gene are associated with susceptibility to essential hypertension,and can cause renal tubular dysgenesis,a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation,and inflammatory bowel disease.