BBC3 Polyclonal Antibody

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Size:

100 μL 25 μL

Verified Samples	Verified Samples in WB: K562 Verified Samples in IHC: Human ovarian cancer
Dilution	WB 1:500-1000, IHC 1:100-1:200
Clonality	Polyclonal
Isotype	IgG
Immunogen	Recombinant Human Bcl-2-binding component 3 protein
Abbre	BBC3
Synonyms	BBC 3, BBC3, BCL 2 binding component 3, BCL2 binding component 3, Bbc3, Bcl-2-binding component 3, JFY 1, JFY-1, JFY1, PUMA alpha, PUMA/JFY1, p53 Upregulated Modulator of Apoptosis, p53 up regulated modulator of apoptosis, p53 up-regulated modulator of apoptosis
Swissprot
Calculated MW	21 kDa
Observed MW	26 kDa
Cellular Localization	Mitochondrion
Concentration	1 mg/mL
Storage	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Buffer	PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4
Purification Method	Antigen Affinity Purification
Research Areas	Cancer, Cell Biology, Metabolism, Signal Transduction
Conjugation	Unconjugated
Background	This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.

Western blot with Flt3 Polyclonal antibody at dilution of 1:1000.lane 1:K562 whole cell lysate

Immunohistochemistry of paraffin-embedded Human ovarian cancer using BBC3 Polyclonal Antibody at dilution of 1:100

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svipmaster@elabscience.cn

武汉市高新大道858号光谷生物医药产业园二期B18栋