CASP4 Polyclonal Antibody

Verified Samples in IHC: Human tonsil, Human colon
Verified Samples in IF: Mouse NIH-3T3

IHC 1:400-1:800, IF 1:50-1:200

Polyclonal

IgG

Recombinant Human CASP4 protein expressed by E.coli

CASP4

Apoptotic cysteine protease Mih1/TX, CASP-4, CASP4, Caspase 4 apoptosis related cysteine peptidase, Caspase-4 subunit 2, Caspase4, ICE(rel)-II, ICE(rel)II, ICEREL II, ICH2, Mih1/TX, Protease ICH-2, Protease TX, TX

Cytosol, AIM2 inflammasome complex, cytosol, IPAF inflammasome complex, NLRP3 inflammasome complex, Endoplasmic reticulum, endoplasmic reticulum, endoplasmic reticulum membrane, Extracellular region or secreted, extracellular region, Mitochondrion, Plasma Membrane, Other locations: protein complex.

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Cancer, Cell Biology, Metabolism

Unconjugated

This gene encodes a member of the cysteine proteases that plays important roles in apoptosis,cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4,apoptosis-related cysteine peptidase",this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9.