Cathepsin L Polyclonal Antibody

Verified Samples in IHC: Human liver, Human placenta

IHC 1:500-1:1000

Polyclonal

IgG

Recombinant Human Cathepsin L protein expressed by Mammalian

Cathepsin L

CATL, CATL1, CTSL, CTSL1, Cathepsin L1, Cathepsin L1 light chain, CathepsinL, FLJ31037, MEP, MGC123162, Major excreted protein, cathepsin L, cb15, ctsl1b, hgg1

Lysosome, Apical cell membrane, Chromaffin granule, Secreted

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Cancer, Neuroscience, Signal Transduction

Unconjugated

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene.