CD22 Polyclonal Antibody

Verified Samples in WB: Human Raji
Verified Samples in IHC: Human tonsil

WB 1:500-1:1000, IHC 1:200-1:400

Polyclonal

IgG

Recombinant Human CD22 protein expressed by E.coli

CD22

B lymphocyte cell adhesion molecule,  BL CAM,  CD 22,  CD22 antigen,  CD22 molecule,  Lectin 2,  Leu14,  Lyb8,  MGC130020,  SIGLEC 2,  T cell surface antigen Leu 14,  sialic acid binding Ig like lectin 2, B cell receptor CD22 precursor

95 kDa

135 kDa

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Cancer, Immunology, Stem Cells

Unconjugated

CD22,also known as Siglec-2 (sialic acid binding Ig-like lectin 2) or BL-CAM (B-lymphocyte cell adhesion molecule),is a 130-140 kDa,B-cell restricted,type I transmembrane glycoprotein belonging to the immunoglobulin gene superfamily. The expression of CD22 is developmentally regulated. It is expressed at low levels in the cytoplasm of pro-B and pre-B cells and present on the cell surface only at mature stages of B-cell differentiation. Cell surface expression is lost during terminal differentiation into plasma cell and after B-cell activation. CD22 is an inhibitory receptor for B-cell receptor (BCR) signalling,preferentially binds to alpha-2,6-linked sialic acid and mediates B-cell B-cell interactions. It plays a crucial role in activation and differentiation of the B-cell.