CD59 Polyclonal Antibody

Verified Samples in WB: Human HUVEC, Human U87-MG, Human Hela
Verified Samples in IHC: Human ovary

WB 1:500-1:1000, IHC 1:250-1:500

Polyclonal

IgG

Recombinant Human CD59 protein expressed by E.coli

CD59

16.3A5, 1F5, 1F5 antigen, 20 kDa homologous restriction factor, CD 59, CD59, CD59 antigen, CD59 antigen complement regulatory protein , CD59 antigen p18 20, CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, CD_antigen=CD59, EJ16, EJ30, EL32 and

14 kDa

14-17 kDa

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Cancer, Cardiovascular, Immunology, Signal Transduction, Stem Cells

Unconjugated

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction.