CD74 Polyclonal Antibody

Verified Samples in IHC: Human tonsil, Human lung cancer, Human breast cancer

IHC 1:50-1:100

Polyclonal

IgG

Recombinant Human CD74 protein expressed by E.coli

CD74

CD 74, CD74 antigen, CD74 antigen (invariant polypeptide of major histocompatibility complex, CD74 molecule, class II antigen-associated), class II invariant chain, CLIP, Gamma chain of class II antigens, HG2A, HLA DR antigens associated invariant chain, HLA DR gamma, HLADR antigens associated invariant chain, HLA-DR antigens-associated invariant chain, HLA-DR-gamma, Ia antigen associated invariant chain, Ia associated invariant chain, Ia gamma, Ia-GAMMA, Invariant polypeptide of major histocompatibility complex class II antigen associated, la-gamma, major histocompatibility complex, Major histocompatibility complex class II invariant chain, MHC HLA DR gamma chain, MHC HLA-DR gamma chain, p35, Protein 41, CD74, DHLAG, HLA class II histocompatibility antigen gamma chain, HLADG, Ia antigen-associated invariant chain, p33, CD 14, CD_antigen=CD14, CD14, CD14 antigen, CD14 molecule, LPS-R, Mo2, Monocyte differentiation antigen CD14, Monocyte differentiation antigen CD14 urinary form, membrane-bound form, Myeloid cell specific leucine rich glycoprotein, Myeloid cell-specific leucine-rich glycoprotein, HLA class II histocompatibility antigen gamma chain, HLADG, Ia antigen-associated invariant chain, Ia-GAMMA II, Ii, p33, CD74 HLA-DR antigens-associated invariant chain, DHLAG, CD74,  invariant chain

Cell membrane, Endosome, Lysosome, Secreted

Detected in urine (at protein level).

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Immunology

Unconjugated

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. Class-II-associated invariant chain peptide Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome.1 Publication Isoform p41 Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2. Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform.