E-Cadherin Polyclonal Antibody

Verified Samples in WB: Mouse spleen, Rat brain
Verified Samples in IHC: Human carcinoma of Colon, Human breast cancer, Human Placenta, Human ovarian cancer

WB 1:500-1:1000, IHC 1:100-1:200

Polyclonal

IgG

Recombinant Human CDH1 protein expressed by E.coli

E-Cadherin

Arc 1, CADH1, CAM 120/80, CD 324, CD324, CD324 antigen, CDHE, Cadherin 1, Cadherin1, E-Cad/CTF3, E-cadherin, ECAD, Epithelial cadherin, LCAM, Liver cell adhesion molecule, UVO, Uvomorulin, cadherin 1 type 1 E-cadherin, cdh1, epithelial calcium dependant adhesion protein

97 kDa

135 kDa

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Cancer, Developmental Biology, Signal Transduction

Unconjugated

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats,a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric,breast,colorectal,thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation,invasion,and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.