Elab Fluor®700 Anti-Human CD194/CCR4 Antibody[L291H4]

CC-CKR-4, CKR4, CMKBR4, ChemR13, HGCN:14099, K5-5, MGC88293

Membrane

L291H4

Mouse IgG1, κ

咨询

CD194, also known as CCR4, is a CC chemokine receptor. It binds CCL17 and CCL22 and is expressed on a subset of T and B cells, basophils, monocytes, and NK cells. Human Th2 cells are characterized by the expression of CCR4 and CCR8, and these receptors are regulated differently during Th2 development. Human peripheral blood Tregs can be divided into two distinct populations based on the expression of CCR4. Freshly isolated Tregs express CCR4 and presumably represent memory-type Tregs, and CCR4- Tregs require CD3-mediated activation to acquire a regulatory activity. Depletion of CCR4+ T cells leads to Th1-type polarization of CD4+ T cells and augmentation of CD8+ T cell responses to tumor antigens. CCR4 and its ligands are important for the recruitment of memory T cells into the skin in various cutaneous immune diseases.

CD194

Mouse

Human

Monoclonal

Elab Fluor®700 Mouse IgG1, κ Isotype Control[MOPC-21]

FCM

Liquid

Elab Fluor®700

Elab Fluor^® 700 is designed to be excited by the Red laser (627-640 nm) and detected using an optical filter centered near 719 nm (e.g., a 725/40 nm bandpass filter).

Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA.

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

12个月

冰袋