Elab Fluor®700 Anti-Mouse Foxp3 Antibody[3G3]

货号：GFH1238M1

Price: ¥3420.00 ¥2160.00 ¥5100.00

Size:

100 Tests 50 Tests 100 Tests × 2

Alternate Names	Forkhead box protein P3, Foxp3, IPEX, JM2
Cellular Localization	Nucleus
Clone No	3G3
Isotype	Mouse IgG1, κ
Leadtime	咨询
Background	Foxp3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of Foxp3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. Foxp3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of Foxp3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of Foxp3 have been reported: one (Foxp3) corresponding to the canonical full-length sequence; the other (Foxp3 δ2) lacking exon 2.
Abbre	Foxp3
Swissprot	Q99JB6
Host	Mouse
Reactivity	Mouse
Clonality	Monoclonal
Isotype Control	Elab Fluor®700 Mouse IgG1, κ Isotype Control[MOPC-21]
Applications	FCM
Form	Liquid
Conjugation	Elab Fluor®700
Conjugation Information	Elab Fluor^® 700 is designed to be excited by the Red laser (627-640 nm) and detected using an optical filter centered near 719 nm (e.g., a 725/40 nm bandpass filter).
Storage Buffer	Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA.
Storage	This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Expiration Date	12个月
Shipping	冰袋
Gene ID	50943,20371,317382

Staining of C57BL/6 murine splenocytes with FITC Anti-Mouse CD4 Antibody[GK1.5] and Elab Fluor^® 700 Anti-Mouse Foxp3 Antibody[3G3] (left) or Elab Fluor^® 700 Mouse IgG1, κ Isotype Control (right). Total viable cells were used for analysis.

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