FAS Polyclonal Antibody

Verified Samples in WB: Hela, Raji
Verified Samples in IHC: Mouse liver

WB 1:500-1:1000, IHC 1:50-1:100

Polyclonal

IgG

Recombinant human Tumor necrosis factor receptor superfamily member 6 protein

FAS

ALPS 1A, ALPS1A, APO 1, APO 1 cell surface antigen, APO1, APO1 cell surface antigen, APT 1, APT1, Apo 1 antigen, Apo-1 antigen, Apo1 antigen, Apoptosis antigen 1, Apoptosis mediating surface antigen FAS, Apoptosis-mediating surface antigen FAS, CD 95, CD 95 antigen, CD95

37 kDa

45 kDa

Secreted and Cell membrane.

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Cancer, Cell Biology, Immunology

Unconjugated

Fas (CD95/APO-1) is a transmembrane glycoprotein belonging to the tumor necrosis factor (TNF) receptor superfamily. It can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains, leading to the formation of the death-inducing signaling complex (DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells,or both. The molecular mass of native Fas is 38 kDa, the high molecular weight form (40-55 kDa) of Fas is due to glycosylation.