GCK Polyclonal Antibody

Verified Samples in WB: Mouse liver
Verified Samples in IHC: Mouse liver
Verified Samples in IF: HepG2

WB 1:1000-1:2000, IHC 1:100-1:200, IF 1:100-1:400

Polyclonal

IgG

Recombinant Mouse Glucokinase protein

GCK

ATP:D-hexose 6-phosphotransferase, FGQTL3, GCK, GK, GLK, Glucokinase, HHF3, HK IV, HK4, HKIV, HXK4, HXKP, Hexokinase D pancreatic isozyme, Hexokinase type IV, Hexokinase-4, Hexokinase-D, LGLK, MODY2

52 kDa

52 kDa

Nucleus. Cytoplasm.

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Cancer, Metabolism, Signal Transduction

Unconjugated

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).