GLα/Galactosidase Alpha Polyclonal Antibody

Verified Samples in WB: MCF-7, 293T
Verified Samples in IHC: Human liver

WB 1:500-1:1000, IHC 1:1000-1:2000

Polyclonal

IgG

Recombinant Human GLα/Galactosidase Alpha protein expressed by Mammalian

GLα

GLA, GALA, Alpha-D-Galactoside, Galactohydrolase, galactosidase alpha, GLAL, Melibiase, Agalsidase, Alpha-galactosidase A, Alpha-D-galactosidase A, Alpha-D-galactoside galactohydrolase, Galactosylgalactosylglucosylceramidase GLA

49 kDa

49 kDa

Lysosome

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Cardiovascular

Unconjugated

alpha -Galactosidase A is a homodimeric glycoprotein that can release terminal alpha -galactosyl moieties from glycolipids and glycoproteins and catalyze the hydrolysis of melibiose into galactose and glucose . It is a lysosomal enzyme and is responsible for degradation of glycolipid globotriaosylceramide (Gb3) (Gal alpha 1‑4Gal beta 1‑4Glc beta ‑ceramide). Mutations in this gene cause Fabry disease, an X-linked hereditary lysosomal storage disease with the accumulation of Gb3 in the walls of small blood vessels, nerves, dorsal root ganglia, renal glomerular and tubular epithelial cells, and cardiomyocytes.