HTRA1 Polyclonal Antibody

Verified Samples in WB: Mouse placenta, Rat placenta
Verified Samples in IHC: Human placenta

WB 1:500-1:1000, IHC 1:400-1:800

Polyclonal

IgG

Recombinant Human HTRA1 protein expressed by E.coli

HTRA1

High-temperature requirement A serine peptidase 1,  L56,  PRSS11,  Serine protease 11, Serine protease HTRA1

51 kDa

51 kDa

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Cancer, Signal transduction

Unconjugated

Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.