IDO1 Polyclonal Antibody

Verified Samples in IHC: Human tonsil

IHC 1:150-1:300

Polyclonal

IgG

Recombinant Human IDO1 protein expressed by E.coli

IDO1

3-dioxygenase, 3-dioxygenase 1, IDO, IDO-1, IDO1, INDO, Indole 2, Indoleamine 2

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Cardiovascular, Metabolism, Signal Transduction

Unconjugated

Indoleamine 2,3-dioxygenase (IDO) is a heme enzyme that initiates the oxidative degradation of the least abundant,essential amino acid,l-tryptophan,along the kynurenine pathway. This protein is normally expressed in the dendritic cells,macrophages,microglia,eosinophils,fibroblasts,endothelial cells,and most tumor cells. IDO activity is associated with immunosuppression and immune attenuation. Several studies showed that IDO can contribute to immune escape when expressed directly in tumor cells or when expressed in immunosuppressive antigen presenting cells such as tolerogenic dendritic cells or tumor associated macrophages. IDO also is a promising therapeutic target for the treatment of cancer,chronic viral infections,and other diseases characterized by pathological immune suppression.