IL-17A Polyclonal Antibody

Verified Samples in IHC: Human tonsil
Human small intestine

IHC 1:500-1:1000

Polyclonal

IgG

Recombinant Rat IL-17A protein expressed by E.coli

IL-17A

Cytotoxic T-lymphocyte-associated antigen, IL-17A, Interleukin-17A, IL-17, CTLA-8, Il17a, Cytotoxic T-lymphocyte-associated antigen 8, Ctla8, Il17, CTLA 8, Cytotoxic T lymphocyte associated antigen 8, Cytotoxic T lymphocyte associated protein 8, Cytotoxic T lymphocyte associated serine esterase 8, IL 17A, Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8), Interleukin 17A, Interleukin17, Interleukin17A, OTTHUMP00000016597, OTTMUSP00000046003

Secreted

Restricted to activated memory T-cells

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Cancer, Immunology

Unconjugated

IL17A,also named as IL-17,is a proinflammatory cytokine. IL-17,synthesized only by memory T cells and natural killer cells,has pleiotropic effects,mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2),as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis,psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein,that is widely expressed on epithelial cells,fibroblasts,B and T cells,and monocytic cells. In psoriatic skin lesions,both Th17 cells and their downstream effector molecules,e.g. IL-17 and IL-22,are highly increased.