Ki67 Polyclonal Antibody

Verified Samples in IHC: Human small intestine
Verified Samples in IHC: Human tonsil
Verified Samples in IHC: Mouse testis
Verified Samples in IHC: Mouse ovary
Verified Samples in IHC: Rat ovary

IHC 1:500-1:1000

Polyclonal

IgG

Recombinant Human Ki67 protein expressed by E.coli

Ki67

MIB, MKI, marker of proliferation Ki, Proliferation marker protein Ki, Antigen identified by monoclonal antibody Ki, PPP1R, MKI67, KIA, MIB-, MIB-1, PPP1R105, marker of proliferation Ki-67, Ki67, Antigen identified by monoclonal antibody Ki-67, Antigen Ki67, Antigen KI-67, Proliferation marker protein Ki-67, Antigen identified by monoclonal Ki 67, Antigen identified by monoclonal Ki-67, MIB 1, Proliferation related Ki 67 antigen, Protein phosphatase 1 regulatory subunit 105, RP11-380J17.2

Nucleus

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Cell Biology, Neuroscience, Tags & Cell Markers, Cancer

Unconjugated

Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface. Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility. Binds DNA, with a preference for supercoiled DNA and AT-rich DNA. Does not contribute to the internal structure of mitotic chromosomes. May play a role in chromatin organization. It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).