LDHA Polyclonal Antibody

Verified Samples in WB: Human Hela, Mouse NIH/3T3, Mouse Kidney, Mouse Heart, Mouse Skeletal muscle, Rat Kidney, Rat Heart, Rat Skeletal muscle
Verified Samples in IHC: Human liver cancer

WB 1:2500-1:5000, IHC 1:200-1:400

Polyclonal

IgG

Recombinant Human LDHA protein expressed by E.coli

LDHA

GSD11,  L lactate dehydrogenase A chain,  LDH M,  LDH muscle subunit,  LDH1,  PIG19 Proliferation-inducing gene 19,  l7R2, Cell proliferation-inducing gene 19 protein

26,30,36,39 kDa

36 kDa

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Cancer, Metabolism, Signal Transduction

Unconjugated

LDHA,also named as LDH-M and NY-REN-59,is an enzyme which catalyzes the inter-conversion of pyruvate and L-lactate with concomitant inter-conversion of NADH and NAD+. LDHA is found in most somatic tissues,though predominantly in muscle tissue and tumours,and belongs to the lactate dehydrogenase family. It has long been known that many human cancers have higher LDHA levels compared to normal tissues. It has also been shown that LDHA plays an important role in the development,invasion and metastasis of malignancies. Mutations in LDHA have been linked to exertional myoglobinuria. LDHA has some isoforms with MW 26-40 kDa.