MCM3 Polyclonal Antibody

Verified Samples in WB: HepG2, PC-12, C6, Raw264.7, NIH/3T3
Verified Samples in IHC: Human lymph node, Human tonsil

WB 1:500-1:1000, IHC 1:50-1:200

Polyclonal

IgG

Recombinant Human DNA replication licensing factor MCM3 protein

MCM3

Cervical cancer proto oncogene 5, DNA polymerase alpha holoenzyme associated P1, HCC 5, HCC5, Human cervical cancer proto oncogene 5, MCM 3, MGC1157, Minichromosome maintenance complex component 3, P1 MCM3, P1 h, P1.h, Replication licensing fa, hRlf beta subunit, p102

91,96 kDa

100 kDa

Chromosome, Nucleus.

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Cancer, Epigenetics and Nuclear Signaling

Unconjugated

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with mCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene.