MMP1 Polyclonal Antibody

Verified Samples in IHC: Mouse lung, Rat lung

IHC 1:50-1:100

Polyclonal

IgG

Recombinant human Matrix metalloprotease 1 protein

MMP-1

27 kDa interstitial collagenase, CLG, CLGN, Fibroblast collagenase, Interstitial collagenase, Matrix Metalloproteinase 1, Matrix metall, Matrix metallopeptidase 1 (interstitial collagenase), Matrix metalloprotease 1, collagenase, fibroblast, interstitial

Secreted>extracellular space>extracellular matrix.

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Cancer, Cell Biology, Cardiovascular, Signal transduction

Unconjugated

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.