PDGF-AA Polyclonal Antibody

Verified Samples in IHC: Human lung cancer, Human placenta

IHC 1:500-1:1000

Polyclonal

IgG

Recombinant Human PDGF-AA protein expressed by E.coli

PDGF-AA

PDGF A, PDGF A chain, Platelet derived growth factor alpha isoform 2 preproprotein, Platelet derived growth factor alpha polypeptide, PDGF1, PDGF-A, PDGFA, PDGF subunit A, PDGF-1, PDGF-AA, PDGFAA, Platelet Derived Growth Factor AA, Platelet derived growth factor alpha chain, Platelet-derived growth factor subunit A, Platelet-derived growth factor A chain, Platelet-derived growth factor alpha polypeptide

Secreted

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Cardiovascular, Signal Transduction, Immunology, Cancer, Metabolism, Developmental Biology

Unconjugated

The platelet-derived growth factor (PDGF) family of disulfide-linked dimeric proteins consists of four homodimeric proteins, PDGF-AA, PDGF-BB, PDGF-CC and PDGF-DD, and one heterodimeric protein, PDGF-AB. Members of this protein family act mainly on connective tissue. The dimeric isoforms of PDGF are expressed by different cell types and at different times during embryonic development. All PDGF isoforms are synthesized as inactive precursors and are processed to active forms that contain a PDGF/VEGF cysteine knot domain. Only PDGF-C and PDGF-D, also named spinal cord-derived growth factors SCDGF and SCDGF-B, also contain an N-terminal CUB domain. Mature PDGF dimers bind and induce the homo- or hetero-dimerization of two receptor tyrosine kinases (PDGF R alpha and R beta).