PSAP Polyclonal Antibody

Verified Samples in WB: A431
Verified Samples in IHC: Mouse brain, Rat brain

WB 1:1000-1:2000, IHC 1:500-1:1000

Polyclonal

IgG

Recombinant Human PSAP protein expressed by Mammalian

PSAP

GLBA, prosaposin, SAP1, SAP, PSAP, GLBA, SAP1, proactivator polypeptide, prosaposin, SAP1p, PSA

58 kDa

60-80 kDa

Lysosome, Secreted

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Signal Transduction, Metabolism

Unconjugated

Prosaposin behaves as a myelinotrophic and neurotrophic factor, whose effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.By similarity Saposins are specific low-molecular mass non-enzymic proteins and participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases. The Prosaposin gets cleaved into 5 chains, Saposin A, B, B-Val, C and D. It also contains several disulfide bonds as well as glycosylation sites.