Purified Anti-Human CD268 Antibody[H353-6G10]

CVID, TNFRSF13C, BAFF-R, BAFFR, BROMIX, CD268, CVID4, prolixin, BAFF R, Tumor Necrosis Factor Receptor Superfamily Member 13C, BR3, BR3, TNFRSF13c, B cell activating factor receptor, BAFF receptor, BAFF receptor (BAFF-R), B-cell-activating factor receptor, BLyS receptor 3, BlySR3, BR 3, CD 268, CD268 antigen, MGC138235, OTTHUMP00000028746, TNFRSF 13C, TR13C, Tumor necrosis factor receptor subunit member 13C

Membrane

H353-6G10

Mouse IgG1, κ

咨询

FCM 2 μg/mL(1×10⁵-5×10⁵ cells)

B-cell activating factor (BAFF), also known as BlyS, TALL-1, TNAK, and zTNF4, is a TNF ligand superfamily member and has been designated TNFSF13B. Produced by macrophages, dendritic cells, and T lymphocytes, BAFF promotes the survival of B cells and is essential for B cell matuRation. BAFF binds to three TNF receptor superfamily members: B-cell matuRation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL (a prolifeRation-inducing ligand), BAFF R selectively binds BAFF. The BAFF R extracellular domain lacks the TNF receptor canonical cysteine-rich domain (CRD) and contains only a partial CRD with four cysteine residues. Human and Mouse BAFF R share 56% aa sequence identity. BAFF R is highly expressed in spleen, lymph node and resting B cells. It is also expressed at lower levels in activated B cell, in resting CD4+ T cells, in thymus and peripheral blood leukocytes. BAFF knockout mice lack mature B cells. Similarly, A/WySnJ mice that are defective in BAFF-R intracellular signaling also lack mature B cells, suggesting that BAFF R is the critical receptor for BAFF during B lymphopoiesis. In contrast, BCMA- or TACI-deficient mice have no major defect in B-cell development. While the function of BCMA is not defined, TACI has been shown to control B-cell homeostasis and T-cell-independent immune responses.

CD268

Mouse

Human

Monoclonal

>98%, Protein A/G purified

FCM

Spleen and lymph node

≥ 1 mg/mL

Unconjugated

Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

12个月

Ice bag