Purified Anti-Mouse CD45 Antibody[M1/9.3.4.HL.3]

B220, CD45, CD45 antigen, CD45R, CD45R0, LCA, L-CA, LY5, protein tyrosine phosphatase, receptor type, Receptor-type tyrosine-protein phosphatase C, T200, Ly-5, Ptprc, c polypeptide, CD 45, GP180, homolog of, Leukocyte common antigen, loc, Lyt-4, OTTHUMP00000033813, OTTHUMP00000033816, OTTHUMP00000033817, OTTHUMP00000038574, Protein tyrosine phosphatase receptor type c polypeptide, protein tyrosine phosphatase, receptor type, C, receptor type C, T200 glycoprotein, T200 leukocyte common antigen

Cell membrane

M1/9.3.4.HL.3

Rat IgG2a, κ

咨询

FCM 2 μg/mL(1×10⁵-5×10⁵ cells)

CD45 is a 180-240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes and platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4.

CD45/PTPRC

Rat

Mouse

Monoclonal

>98%, Protein A/G purified

FCM

≥ 1 mg/mL

Unconjugated

Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

12个月

Ice bag