RBP3 Polyclonal Antibody

Verified Samples in IHC: Mouse retina, Rat retina

IHC 1:50-1:100

Polyclonal

IgG

Recombinant human Retinol-binding protein 3 protein

RBP3

D10S64, D10S65, D10S66, IRBP, Interphotoreceptor retinoid binding protein, Interphotoreceptor retinoid-binding protein, Interstitial retinol binding protein, Interstitial retinol-binding protein, RBP 3, RBPI, RET3, Retinol binding prot, Retinol binding protein 3, rbp3

Secreted>extracellular space>extracellular matrix>interphotoreceptor matrix. Interphotoreceptor matrix that permeates the space between the retina and the contiguous layer of pigment epithelium cells.

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Neuroscience

Unconjugated

Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively.