Recombinant Human CDH1 Protein (His Tag)

Arc 1;CADH1;CAM 120/80;CD 324;CD324;CD324 antigen;CDHE;Cadherin 1;Cadherin1;E-Cad/CTF3;E-cadherin;ECAD;Epithelial cadherin;LCAM;Liver cell adhesion molecule;UVO;Uvomorulin;cadherin 1 type 1 E-cadherin;cdh1;epithelial calcium dependant adhesion protein

E.coli

Asp155-Phe375

P12830-1

Human

23.9 kDa

35 kDa

N-His

Not validated for activity

> 85% as determined by reducing SDS-PAGE.

< 10 EU/mg of the protein as determined by the LAL method

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

This product is provided as lyophilized powder which is shipped with ice packs.

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.