Recombinant Human IL22 Protein(Avi,His Tag)
- 货号：GPEH0867
Price:
| 别称 |
UNQ;IL-D;Interleukin;Cytokine Zcyto;TIFIL;zcyto;IL22;IL-21;IL-22;IL-D110;IL-TIF;ILTIF;TIFIL-23;TIFa;zcyto18;UNQ3099/PRO10096;UNQ3099;Interleukin-22;Cytokine Zcyto18;IL-10-related T-cell-derived-inducible factor;PRO10096;IL-D110;ILTIF;IL-TIF;TIFa;TIFIL-23;zcyto18
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| 表达系统 |
E.coli
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| 序列 |
Gln29-Asp109
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| 蛋白编码 |
Q9GZX6
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| 种属 |
Human
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| 计算分子量 |
8.8 kDa
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| 表观分子量 |
15 kDa
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| 标签 |
C-Avi-His
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| 生物活性 |
Not validated for activity
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| 纯度 |
> 95% as determined by reducing SDS-PAGE.
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| 内毒素 |
< 10 EU/mg of the protein as determined by the LAL method
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
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| 复溶方法 |
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
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| 背景 |
Interleukin-22(IL-22) is a member of a group of the IL-10 family, a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding protein, IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A.
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