Recombinant Human KDR Protein( Fc Tag)

CD309;CD309 antigen;EC 2.7.10.1;Fetal liver kinase 1;FLK-1;FLK1;FLK1;mouse;homolog of;Kdr;Kinase insert domain receptor (a type III receptor tyrosine kinase);Kinase insert domain receptor;KRD1;Ly73;Protein tyrosine kinase receptor FLK1;Protein-tyrosine kinase receptor flk-1;soluble VEGFR2;Tyrosine kinase growth factor receptor;Vascular endothelial growth factor receptor 2;VEGFR 2;VEGFR;VEGFR-2;VEGFR2;VGFR2

Mammalian

Ala20-Glu764

P35968

Human

106.8 kDa

100-120 kDa

C-Fc

Not validated for activity

> 90% as determined by reducing SDS-PAGE.

< 1.0 EU/mg of the protein as determined by the LAL method

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

This product is provided as lyophilized powder which is shipped with ice packs.

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.