Recombinant Human RANTES Protein(Trx Tag)

Beta chemokine RANTES;Beta chemokine RANTES precursor;C C motif chemokine 5;CCL 5;CCL5;CCL5_HUMAN;Chemokine (C C motif) ligand 5;Chemokine CC Motif Ligand 5;D17S136E;EoCP;Eosinophil chemotactic cytokine;MGC17164;RANTES(4-68);Regulated upon activation normally T expressed and presumably secreted;SCYA 5;SCYA5;SIS delta;SIS-delta;SISd;Small inducible cytokine A5;Small inducible cytokine A5 (RANTES);Small inducible cytokine subfamily A (Cys Cys) member 5;Small-inducible cytokine A5;T cell specific protein p288

E.coli

Ser24-Ser91

P13501

Human

27.4 kDa

31 kDa

N-Trx

Not validated for activity

> 90% as determined by reducing SDS-PAGE.

< 10 EU/mg of the protein as determined by the LAL method

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

This product is provided as lyophilized powder which is shipped with ice packs.

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils