Recombinant Mouse IL-23A Protein(Fc Tag)

IL 23;IL 23 A;IL 23 subunit alpha;IL 23A;IL 23p19;IL-23 subunit alpha;IL-23-A;IL-23p19;IL12B;IL23;Il23a;IL23A_HUMAN;IL23P19;interleukin 12B;Interleukin 23 alpha subunit p19;Interleukin 23 p19 subunit;interleukin 23 subunit alpha;interleukin 23 subunit p19;interleukin six, G CSF related factor;Interleukin-23 subunit alpha;Interleukin-23 subunit p19;JKA3 induced upon T cell activation;MGC79388;P19;SGRF

Mammalian

Val22-Ala196

Q9EQ14

Mouse

44.1 kDa

40-50 kDa

C-Fc

Not validated for activity

> 90% as determined by reducing SDS-PAGE.

< 1.0 EU/mg of the protein as determined by the LAL method

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

This product is provided as lyophilized powder which is shipped with ice packs.

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

IL-23, which is mainly secreted by antigen-presenting cells, is a member of the IL-12 family, which includes IL-12, IL-27, and IL-35. IL-23 is a heterodimeric cytokine, comprised of a unique p19 subunit and p4 subunit, the latter of which is shared with IL-12. The receptor for IL-23 consists of IL-23R and IL-12Rβ1, the latter of which is also characteristic of IL-12. IL-23 is essential for Th17 differentiation, expansion, and survival by binding to its receptor, thereby activating the signaling pathway. Many studies revealed that the IL-23/Th17 pathway is implicated in the pathophysiology of various autoimmune diseases, such as autoimmune arthritis, primary biliary cirrhosis, and inflammatory bowel disease.