S100A4 Polyclonal Antibody

Verified Samples in IHC: Human lung, Mouse colon, Mouse lung, Rat colon, Rat lung

IHC 1:50-1:200

Polyclonal

IgG

Recombinant Mouse Protein S100-A4 protein

S100A4

,  42A,  CAPL,  Calvasculin,  FSP1,  Fibroblast specific protein 1,  Leukemia multidrug resistance associated protein,  MTS1,  Malignant transformation suppression 1,  Metastasin,  OTTHUMP00000015467,  OTTHUMP00000015468,  P9KA,  PEL98,  calcium Placental protein, 18A2

Nucleus

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Cardiovascular, Signal Transduction, Cancer

Unconjugated

S100A4 is a member of the S100 family of calcium-binding proteins. The S100 family members have been involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A4 is known to localize to and function in the nucleus, cytoplasm of cells and the extracellular space. S100A4 has also been shown to be associated with tumor growth, motility, invasion, metastasis, angiogenesis, apoptosis and chemoresistance. It is a fibroblast-specific protein associated with mesenchymal cell morphology and motility, is expressed during epithelial-mesenchymal transformations (EMT) in vivo. It is an improved marker for lung fibroblasts that could be useful for investigating the pathogenesis of pulmonary fibrosis. Overexpression of S100A4 is correlated with a worse prognosis inpatients with various types of cancer.