SDHB Polyclonal Antibody

Verified Samples in IHC: Human liver, Human kidney

IHC 1:75-1:150

Polyclonal

IgG

Recombinant Human SDHB protein expressed by E.coli

SDHB

Ip,  DHSB,  Iron sulfur subunit,  Iron sulfur subunit of complex II,  Iron-sulfur subunit of complex II,  PGL 4,  PGL4,  SDH,  SDH 1,  SDH1,  SDH2,  SDHIP,  SdhB,  Succinate dehydrogenase [ubiquinone] iron sulfur protein mitocho,  homolog of,  mitochondrial, CWS2

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Cancer, Cell Biology, Metabolism, Signal Transduction

Unconjugated

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.