STAT1 Polyclonal Antibody

Verified Samples in WB: Mouse lung, Hela, A549
Verified Samples in IHC: Rat liver, Human spleen

WB 1:500-1:1000, IHC 1:50-1:100

Polyclonal

IgG

Recombinant Human STAT1 Protein expressed by E.coli

STAT1

CANDF7, DKFZp686B04100, IMD31A, IMD31B, IMD31C, ISGF 3, ISGF-3, OTTHUMP00000163552, OTTHUMP00000165046, OTTHUMP00000165047, OTTHUMP00000205845, Signal tr, Signal transducer and activator of transcription 1 91kD, Signal transducer and activator of transcription 1 91kDa

87 kDa

87 kDa

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Cancer, Epigenetics and Nuclear Signaling, Signal Transduction

Unconjugated

Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors,Jak kinases (TYK2 and JAK1) are activated,leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize,associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor,that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes,which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma),STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF),migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes,inducing a cellular antiviral state.