UMOD Polyclonal Antibody

Verified Samples in IHC: Human kidney

IHC 1:100-1:200

Polyclonal

IgG

Recombinant Human UMOD protein expressed by E.coli

UMOD

Tamm-Horsfa, ADMCKD2, FJHN, HNFJ, HNFJ1, MCKD2, THGP, THP, Tamm Horsfall glycoprotein, Tamm Horsfall urinary glycoprotein, Tamm-Horsfall urinary glycoprotein, UROM_HUMAN, Umod, Urehd1, medullary cystic kidney disease 2 (autosomal dominant), urehr4, uromodulin (uromucoid

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Cancer, Cell Biology

Unconjugated

The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants.