AF/LE Purified Anti-Mouse CD272/BTLA Antibody[PK18.6]
![AF/LE Purified Anti-Mouse CD272/BTLA Antibody[PK18.6]](http://files.elabscience.cn/assets/images/loading.png)
Price:
Size:
100 μg
25 μg
- 应用性： FCM
- 亚型： Rat IgG1, κ
- 宿主： Rat
| Alternate Names | B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein, Btla, CD272 |
| Clone No | |
| Isotype | Rat IgG1, κ |
| Leadtime |
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| Background |
B and T lymphocyte attenuator (BTLA) is an Ig superfamily coinhibitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand Herpes Virus Entry Mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8<sup>+</sup> memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4<sup>+</sup> and CD8<sup>+</sup> T cells in vivo. Tolerant T cells have significant up-regulated expression of BTLA compared with effector and naive T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It has been reported that BTLA may regulate T cell function through binding to B7-H4.
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| Abbre | CD272/BTLA |
| Swissprot | |
| Host | Rat |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Applications | |
| Research Areas | Immunology;Inhibitory Molecules |
| Concentration | ≥ 1 mg/mL |
| Conjugation | None (AF/LE) |
| Storage Buffer | Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Expiration Date | 12个月 |
| Shipping |
Ice bag |
| E-AB-F1024A | Purified Anti-Mouse CD272/BTLA Antibody[PK18.6] | 100 μg , 25 μg |
| E-AB-F1024B | Biotin Anti-Mouse CD272/BTLA Antibody[PK18.6] | 100μg , 25μg |
| E-AB-F1024C | FITC Anti-Mouse CD272/BTLA Antibody[PK18.6] | 100Tests , 50Tests , 100Tests×2 |
| E-AB-F1024D | PE Anti-Mouse CD272/BTLA Antibody[PK18.6] | 100Tests , 50Tests , 100Tests×2 |
| E-AB-F1024E | APC Anti-Mouse CD272/BTLA Antibody[PK18.6] | 100Tests , 50Tests , 100Tests×2 |
| E-AB-F1024H | PE/Cyanine7 Anti-Mouse CD272/BTLA Antibody[PK18.6] | 100Tests , 50Tests , 100Tests×2 |
| E-AB-F1024UC | FITC Anti-Mouse CD272/BTLA Antibody[PK18.6] | 100μg , 25μg |
| E-AB-F1024UD | PE Anti-Mouse CD272/BTLA Antibody[PK18.6] | 100μg , 25μg |
| E-AB-F1024UE | APC Anti-Mouse CD272/BTLA Antibody[PK18.6] | 100μg , 25μg |
| E-AB-F1024UH | PE/Cyanine7 Anti-Mouse CD272/BTLA Antibody[PK18.6] | 100μg , 25μg |
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