Aβ derives from APP via proteolytic cleavage by proteases called α- , β- and γ-secretase. The α-secretase cleavage precludes the formation of Aβ , while the β- and γ-cleavages generate APP components with amyloidogenic features. Amyloid beta A4 precursor protein ( APP ) , encoded by APP gene which locate on human chromosome 21q , is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth , neuronal adhesion and axonogenesis. APP expressed in all fetal tissues and is pronounced in brain , kidney , heart and spleen , but weak in liver. Defects in APP are the cause of Alzheimer disease type 1 ( AD1 ) . This antibody can recogniaze the N-terminus of human APP: Soluble APP-alpha and Soluble APP-beta.

Abeta 40;amyloid beta 40;Beta-amyloid protein 40;Aβ ( 1-40 );Aβ40;Amyloid Beta 40

Human

PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5; PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5

-20℃

12个月