Metalloproteinase that plays an important role in connective tissue organization , development , inflammation and cell migration. Extracellular matrix ( ECM ) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans ( CSPGs ) including ACAN , VCAN , BCAN and NCAN.Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development , including limb and cardiac morphogenesis , and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts , facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration.Participates in development of brown adipose tissue and browning of white adipose tissue.Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection.

ADAMTS5;ADAM-TS 11;ADAM-TS 5;ADAM-TS5;ADAMTS-11;ADAMTS-5;ADAMTS11;ADMP-2;ADAM metallopeptidase with thrombospondin type 1 motif 5

Human

PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5; PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5

-20℃

12个月