This gene encodes a member of the S1 , or chymotrypsin , family of serine peptidases. This protease catalyzes the cleavage of factor B , the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine , a cell signaling protein secreted by adipocytes , which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency , which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease.

ADN;Adipsin;DF;PFD;Factor D;Properdin Factor D Esterase

Human

PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5; PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5

-20℃

12个月