Protein tyrosine kinase that is part of several cell surface receptor complexes , but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex , although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules ( MTs ) . Upon ERBB2 activation , the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2 , allowing its association with the cell membrane. In turn , membrane-bound APC allows the localization of MACF1 to the cell membrane , which is required for microtubule capture and stabilization.In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A , the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.

ERBB2;HER2;CD340;p185;MLN 19;NEU

Human

PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5; PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5

-20℃

12个月