Endostatin is a C-terminal proteolytic fragment of collagen XVIII α1 (Col 18) that is localized in the vascular basement membrane of almost all epithelia and endothelia.     Endostatin is produced from catalytic cleavage from MMPs,cathepsin L,and S. It is detected in circulation at a physiologic level of 20 to 50 ng/ml in serum.     Endostatin interacts with multiple molecules including heparin,heparan sulfate,chondroitin sulfate,dermatan sulfate,thrombospondin-1,SPARC,collagens (I,IV,and VI),the amyloid peptide Aβ (1-42),transglutaminase-2,and among others.     Endostatins derived from collagens XV and XVIII differ in structure and binding properties,tissue distribution,and anti-angiogenic activity.     Endostatin is an endogenous angiostatic factor that induces apoptosis in endothelial cells and inhibits endothelial cell migration in vitro.

COL18A1;collagen alpha-1(XVIII) chain;collagen;type XVIII;alpha 1;Endostatin;FLJ27325;FLJ34914;human type XVIII collagen 10 endostatin;KNO

Human

Detects Human ES in ELISAs

Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4; Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4

-20℃

12个月