This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form , and is converted to an active form by either factor IXa , factor Xa , factor XIIa , or thrombin by minor proteolysis. Upon activation of the factor VII , a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated , and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions , the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

FVII;Proconvertin;SPCA

Human

PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5; PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5

-20℃

12个月