FGF-1,one of the most studied members of the fibroblast growth factor family,is a powerful mitogen exhibiting strong action on many different cell types.   FGF-1 activity can be mediated not only by autocrine/paracrine pathways but also by an intracrine pathway.   FGF-1 lacks a secretion signal peptide and is exported through a non-classical pathway.   Endogenous FGF-1 is found in the nucleus of most cell types.   Nuclear localization is required for FGF-1 mitogenic activity.   FGF-1 promotes tumor development by promoting cancer cell proliferation and survival.   Increased FGF-1 expression in early stages of many different cancers has been reported.  Under oxidative stress,astrocytes can also release FGF-1 which stimulates ApoE/HDL generation in an autocrine manner for protection of the brain against oxidative stress.   Involvement of FGF-1 in inflammation,cardioprotection,wound healing,adipocyte remodeling,and restenosis is also reported.

FGF-1;ECGF;ECGF-beta;A-FGF;FGFA;ECGFA;ECGFB;FGF-Alpha;HBGF1;HBGF-1;ECGFB;GLIO703;Heparin-binding growth factor 1

Human

Detects Human FGF1 in ELISAs

Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4; Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4

-20℃

12个月