Folate receptor 1 ( FOLR1 ) ;also known as folate receptor alpha or adult folate-binding protein ( FBP ) ;is a 38-kDa glycoprotein belonging to the folate receptor family . The receptor binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. FOLR1 is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. FOLR1 expression is often limited to the apical surfaces of epithelium in the lung;kidney and choroid plexus but is differentially overexpressed in a variety of solid tumors such as ovarian cancer;non-small cell lung cancer;breast cancer;kidney cancer and high-grade osteosarcoma .

FBP;FOLR;FR-alpha;Folate receptor alpha;MOv18;Adult folate-binding protein;KB cells FBP;Ovarian tumor-associated antigen MOv18

Human

PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5; PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5

-20℃

12个月