T cell immunoglobulin and mucin domain-3 ( TIM3 ) , also called hepatitis A virus cellular receptor 2 ( HAVCR2 ) , isa transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important rolein the Th1-mediated immune response. TIM3 is expressed on the Th1 cells , CD8 T-cells , monocytes , anddendritic cells , but not on Th2 cells. TIM3 expressed by monocytes and dendritic cells facilitates phagocytosisof apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interactionwith phosphatidylserine. Engagement of TIM3 by its ligand galectin-9 induces a range of immunosuppressivefunctions which enhance immune tolerance and inhibit anti-tumor immunity. Stimulation of TIM3 with anagonistic antibody promotes inflammation through the activation of innate immune cells. TIM3 is alsoregarded as a potential target molecule for immunotherapy. TIM3 and programmed cell death 1 ( PD-1 ) as twoimportant coinhibitory regulators of T cell responses , have been implicated with the T-cell dysfunction orexhaustion associated with chronic HBV infection including HBV-related HCC.

T cell immunoglobulin and mucin domain containing protein 3;hepatitis virus cellular receptor 2;CD366

Human

PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5; PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5

-20℃

12个月