Heparin-binding EGF-like growth factor ( HB-EGF ) is a 12-16 kDa member of the epidermal growth factor ( EGF ) family. It possesses an EGF-like domain , and a heparin-binding motif. Mature HB-EGF is a soluble peptide thatarises from proteolytic processing of the transmembrane form. Human HB -EGF shows 76% and 73% aasequence identity with rat and mouse HB-EGF , respectively. It is required for normal cardiac valve formationand normal heart function , promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation , it is mitogenic for fibroblasts , but not endothelial cells. HB-EGF classified as agroup 2 ErbB ligand based on its ability to activate both the EGF/ErbB1 and ErbB4 receptors. Activityassociated with ErbB4 binding appears to be limited to non -mitogenic actions , while EGFR binding inducesboth mitogenic and non-mitogenic activity.

DTR;DTS;DTSF;Diphtheria Toxin Receptor;Diphtheria toxin receptor;HB-EGF;HEGFL;Proheparin-binding EGF-like growth factor

Human

PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5; PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5

-20℃

12个月