HP(Haptoglobin) is also named as zonulin and belongs to the peptidase S1 family. HP,a plasma glycoprotein that binds free hemoglobin,has a tetrameric structure of 2 alpha(16 kDa and 9 kDa) and 2 beta(40 kDa) polypeptides that are covalently associated by disulfide bonds. In most species,apart from ruminants,Hp has a molecular mass of 100 kDa,consisting of two subunits of 40 kDa and two subunits of 9 kDa,although in a few species,such as man,genetic variant of Hp forms polymers of higher mass. Recent studies of haptoglobin show that certain oligosaccharide structures predominate in different diseases. For example,a highly-fucosylated structure is found in breast cancer and ovarian cancer,highly-sialylated structures in Crohn’s disease and highly branched structures in alcoholic liver disease and fucosylated haptoglobin is a good serum marker for pancreatic cancer..

HP;BP;HP2ALPHA2;HPA1S;Haptoglobin;Zonulin

Human

Detects Human HP in ELISAs

Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4; Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4

-20℃

12个月