Constant region of immunoglobulin heavy chains. Immunoglobulins , also known as antibodies , are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity , the membrane-bound immunoglobulins serve as receptors which , upon binding of a specific antigen , trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity , which results in the elimination of bound antigens.The antigen binding site is formed by the variable domain of one heavy chain , together with that of its associated light chain. Thus , each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V- ( D ) -J rearrangement and can then be subjected to somatic hypermutations which , after exposure to antigen and selection , allow affinity maturation for a particular antigen

IGHG3

Human

PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5; PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5

-20℃

12个月