Interleukin-22 (IL-22),also known as IL-10-related T cell-derived inducible factor (IL-TIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. Mouse IL-22 cDNA encodes a 179 amino acid (aa) residue protein with a putative 33 aa signal peptide that is cleaved to generate a 147 aa mature protein that shares approximately 79% and 22% aa sequence identity with human IL-22 and IL-10,respectively. The mouse IL-22 gene is localized to chromosome 10. Although it exists as a single copy gene in many mouse strains,the IL-22 gene is duplicated in some mouse strains including C57B1/6,FVB and 129. The two mouse genes designated IL-TIF alpha and IL-TIF beta,share greater than 98% sequence homology in their coding region. IL-22 has been shown to activate STAT1 and STAT3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal mouse T cells upon Con A activation. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection,suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits,IL-22 R (previously an orphan receptor named CRF2-9) and IL-10 R beta (previously known as CRF2-4),belonging to the class II cytokine receptor family.

IL22;IL-22;IL-D110;IL-TIF;ILTIF;TIFIL-23;TIFa;zcyto18;UNQ3099;PRO10096

Human

Detects Human IL-22 in ELISAs

Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4; Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4

-20℃

12个月